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GENES CELLS (1996) 1, 269-275.
Copyright © 1996 Blackwell Publishing or its licensors

Original Article

A new view of V(D)J recombination

M Gellert

The DNA rearrangement that assembles antibody and T cell receptor genes is beginning to be understood. New work shows that the first step is a site-specific cleavage which can be performed by purified RAG1 and RAG2 proteins. The later steps largely overlap with the repair of radiation-induced DNA double-strand breaks, as indicated by the identity of several newly cloned factors. These developments open the way for a thorough biochemical study of V(D)J recombination.


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