HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE ADVANCED SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martin-Lannerée, S. Articles by Plessis, A. Search for Related Content PubMed Articles by Martin-Lannerée, S. Articles by Plessis, A.

Laboratoire de Génétique du Développement et Évolution, Institut Jacques Monod, UMR 7592 CNRS Université Paris 6 et Paris 7, 2 place Jussieu, 75 251 Paris Cedex 05, France

In human, the myeloid leukemia factor 1 (hMLF1) has been shown to be involved in acute leukemia, and mlf related genes are present in many animals. Despite their extensive representation and their good conservation, very little is understood about their function. In Drosophila, dMLF physically interacts with both the transcription regulatory factor DREF and an antagonist of the Hedgehog pathway, Suppressor of Fused, whose over-expression in the fly suppresses the toxicity induced by polyglutamine. No connection between these data has, however, been established. Here, we show that dmlf is widely and dynamically expressed during fly development. We isolated and analyzed the first dmlf mutants: embryos lacking maternal dmlf product have a low viability with no specific defect, and dmlf^-– adults display weak phenotypes. We monitored dMLF subcellular localization in the fly and cultured cells. We were able to show that, although generally nuclear, dMLF can also be cytoplasmic, depending on the developmental context. Furthermore, two differently spliced variants of dMLF display differential subcellular localization, allowing the identification of regions of dMLF potentially important for its localization. Finally, we demonstrate that dMLF can act developmentally and postdevelopmentally to suppress neurodegeneration and premature aging in a cerebellar ataxia model.

Present address: ^aDépartement d’Hématologie, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes, 75014 Paris, France;

^bSchool of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK;

^cDevelopmental Biology Programme, EMMeyerhofstrasse 1, 69117 Heidelberg, Germany

^* Correspondence: E-mail: plessis{at}ijm.jussieu.fr

This article has been cited by other articles:

				E.-S. Kim, Y. H. Hong, and H. S. Lillehoj Genetic effects analysis of myeloid leukemia factor 2 and T cell receptor-{beta} on resistance to coccidiosis in chickens Poult. Sci., January 1, 2010; 89(1): 20 - 27. [Abstract] [Full Text] [PDF]