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Genes to Cells (2006) 11, 383-396. doi:10.1111/j.1365-2443.2006.00945.x
© 2006 Blackwell Publishing or its licensors
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OMA-1 is a P granules-associated protein that is required for germline specification in Caenorhabditis elegans embryos

Masumi Shimada, Hideyoshi Yokosawa and Hiroyuki Kawahara*

Department of Biochemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan

In Caenorhabditis elegans, CCCH-type zinc-finger proteins have been shown to be involved in the differentiation of germ cells during embryonic development. Previously, we and others have identified novel redundant CCCH-type zinc-finger proteins, OMA-1 and OMA-2, that are involved in oocyte maturation. In this study, we report that the cytoplasmic expression level of OMA-1 protein was largely reduced after fertilization. In contrast to its cytoplasmic degradation, OMA-1 was found to accumulate exclusively on P granules in germline blastomeres during embryogenesis. A notable finding is that embryos with partially suppressed oma-1; oma-2 expression showed inappropriate germline specification, including abnormal distributions of PGL-1, MEX-1 and PIE-1 proteins. Thus, our results suggest that oma gene products are novel multifunctional proteins that participate in crucial processes for germline specification during embryonic development.

Communicated by: Masayuki Yamamoto

* Correspondence: E-mail: kawahara{at}pharm.hokudai.ac.jp




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