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Sylvain Brun^1,, Sheila Vidal^1,, Paul Spellman², Kuniaki Takahashi³, Hervé Tricoire⁴ and Bruno Lemaitre^1,*

¹ Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France
² Department of Molecular and Cell Biology and Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3200, USA
³ National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan
⁴ Institut Jacques Monod, 2 place Jussieu, 75251 Paris, France

Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila.

These authors contributed equally to this work.

Communicated by: Konrad Basler

^* Correspondence: E-mail: lemaitre{at}cgm.cnrs-gif.fr