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Front cover: Geminin^+/+ embryo (left) and geminin^-/-(right). Mouse embryos at E3.5 were stained with antibodies to phosphorylated histone H3 (red), anti-β-catenin (green) and DAPI (blue). Cells of geminin^-/- embryo entered S phase but not M phase. For detail see the article by K. Hara et al. in this issue (pp.1281–1293 ).