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Front cover: Knockdown of a heme synthesis enzyme coproporphyrinogen oxidase (CPO) using anti-sense morpholinos (CPO-MO) induces a significant suppression of hemoglobin production (left panels). Injection of human CPO RNA restores hemoglobin production in the CPO-MO-injected embryos (right panels). o-dianisidine staining at 48 hour post fertilization (hpf) (upper panels). Color of blood cells in heart at 76 hpf (bottom panels). For details see the article by R. Hanaoka et al. in this issue (pp. 293–303).