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Front cover: The RGK-family members of small GTPases are well known to contain crucial substitutions in the functional motifs that are conserved in all other small GTPases. The first crystal structure of an RGK-family member, human Rad (Ras associated with diabetes), reveals unexpected conformational flexibility of both switch I and II regions. The unexpected flexibility is shown to be cased by nonconservative substitutions in the G2 and G3 motifs forming the switch regions together with other crucial substitutions in the structural elements interacting with the switches. For detail see the article by Yanuar et al. in this issue (pp. 961–968).