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Front cover: At heterochromatic regions and transcriptionally-inactive loci in the genome, methylation at lysines 9 and 27 (red circles) of histone H3 is often found. Hypermethylated CpGs regions are found in such heterochromatic resions, whereas hypomethylated regions are associated with relaxed chromatin. Genome-wide profile of DNA methylation at tissue-dependent and differentially methylated regions (T-DMRs) is unique to distinct cell-types and tissues. K. Ikegami et al. showed that deficiency of a histone H3-K9/K27 methyltransferase G9a caused DNA demethylation at 32 loci (arrowheads) in mouse ES cells and confirmed these loci to be targets of G9a by chromatin immunoprecipitation. For detail see K. Ikegami et al. in this issue (pp. 1–11).