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Front cover: T. Hayashi and colleagues found that Tel2 protein physically interacts with all the PIKKs (phosphoinositide 3-kinase-related kinases) including Tor1, Tor2, Rad3 (ATR) and Tel1 (ATM) in fission yeast. Tel2 may serve as a link between TOR nutritional signalings and DNA damage checkpoints. For details, see the article by T. Hayashi et al . (pp. 1357–1370) and the review by J. Kanoh & M. Yanagida (pp. 1301–1304) in this issue.