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Front cover: Top: Autophagic bodies visualized in a fission yeast cell. The S. pombe isp6Δ mutant, which is deficient in a vacuolar protease, initiates autophagy under nitrogen starvation. However, degradation of autophagic bodies is strongly suppressed in this mutant strain, resulting in the accumulation of noticeable autophagic bodies in vacuoles, which can be seen as spherical objects containing a small portion of cytoplasm. A transmission electron micrograph of a cell (taken by Mami Konomi). For details see Kohda, T. A. et al. in this issue (pp. 155–170). Bottom: Monitoring autophagy in the yeast, Saccharomyces cerevisiae with GFP-Atg8p. Cells grown in the nutrient-rich medium (left) were treated with rapamycin to induce autophagy (right). GFP-Atg8p was transported into the vacuole by autophagy. GFP-Atg8p (green) and cell walls stained with calcofluor (red). For details see K. Suzuki et al. in this issue (pp.209–218 ).
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