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Front cover: PC12 cells retrovirally expressing kinase-dead mutant of human BREK (DN-BREK) were stimulated with 100 ng/ml NGF for 2 days. The data show that DN-BREK facilitated neurite extension, suggesting that BREK is involved in NGF signalling. For details, see the article by Kawa et al. in this issue (pp. 219-232).